Every European clinical trial software tool reviewed
Munich, Germany
Monthly SaaS fee plus one-time set-up fee per active study; no figures published
Demo on request
Best for: Device and pharma teams that prefer per-study pricing with unlimited users
Climedo is a Munich vendor of EDC, eCOA, eConsent and televisits whose billing is built around the study, not the seat. The site describes a monthly fee and a one-time set-up fee per active study, with unlimited users and sites in each package, and support sold separately in bronze, silver and gold tiers. Patients can answer through an SMS or email link or a QR code without installing an app.
Climedo Health GmbH is registered in Munich as HRB 233195, and the pages state Frankfurt servers on an AWS region, with US hosting only on request. According to the vendor, the system is auditable against ICH GCP, GAMP5 and FDA 21 CFR Part 11, and study data sits with an ISO 27001-certified hosting partner. The founding year and owner are not stated, and no CTMS or eTMF is listed.
What Climedo does well
- Users and sites are unlimited in every package
- Servers in Frankfurt, stated on its own pages
- GmbH with a register entry in Munich
- eCOA, eConsent and televisits in one product
- Link or QR code entry, no app needed
Where Climedo falls short
- Fee structure shown, no amounts
- Frankfurt hosting runs on AWS
- Nothing for CTMS or eTMF
- Founding year and owner missing from the pages checked
Standout feature. Climedo prices by active study with unlimited users and sites, so adding investigators does not raise the fee.
Munich, Germany
Not published; contact the vendor for a quote
Demo on request
Best for: Teams that want CDISC structure and randomization together in a system hosted in Germany
Marvin EDC is a CDISC-native EDC that the vendor positions as a certified platform, with RTSM for randomization and material handling, ePRO, a separate safety module and eConsent as an add-on. Its AI-assisted eCRF creation drafts a form from the protocol, adds edit checks and generates synthetic patients for testing before real data enters.
The operator is AB Cube Germany GmbH in Munich, and the old xclinical.com domain now redirects to marvin.now. The FAQ names Noris Network and Hetzner as the two German hosting providers, and the site reports their data centres as ISO 27001, TUVIT and ISAE 3402 certified. The GCP and 21 CFR Part 11 line is a claim, so ask for the validation package. The parent group behind AB Cube is not described.
What Marvin EDC does well
- Hosting providers in Germany named by the vendor
- Built around CDISC from the start
- RTSM and ePRO from the same family
- Test patients generated for form checks
- APIs and a Data Hub for integration
Where Marvin EDC falls short
- No price on the site
- Owning group not named
- CTMS and eTMF absent from the product list
- Part 11 wording is a claim, not a certificate
Standout feature. Marvin EDC creates synthetic patients to test an eCRF before go-live.
Oslo, Norway
Base plans EUR 10 (Personal), EUR 25 (Professional/Team), EUR 45 (Organisation) per seat per month billed annually; trial features quoted per project plus a one-time startup cost
Demo on request
Best for: Academic groups and small CROs that want visible prices and a free test build
Ledidi is an Oslo platform for clinical trials and registries that shows its base plans in euro on a public page: EUR 10 per seat per month for Personal, EUR 25 for Professional or Team, and EUR 45 for Organisation, billed annually. Trial functions are priced per project through a calculator plus a one-time startup cost, so the first number is not the final one.
Ledidi AS carries enterprise number 917 137 137. Norway is in the EEA, so the contracting entity is European even outside the EU. Data is stored in the AWS Frankfurt region with backups in Stockholm, and the site mentions confidential computing and end-to-end encryption. Design Mode costs nothing until go-live, a 30-day trial exists, and the AI Study Builder drafts a structure from an uploaded protocol. Ownership is not stated.
What Ledidi does well
- Seat prices in euro on a public page
- No charge for Design Mode until go-live
- Frankfurt primary, Stockholm backups
- One platform for trials and registries
- Trial period of 30 days
Where Ledidi falls short
- Trial cost depends on a calculator or quote
- Runs on AWS
- Owner not named
- Nothing for CTMS or eTMF
Standout feature. Ledidi lets a team build and test a study in Design Mode at no charge until the project goes live.
Amsterdam, Netherlands
Founded 2012
Pricing on request; itemised fixed-scope proposal
Demo on request
Best for: Teams that want to take only some modules and decide how much of the build the vendor does
Castor splits its platform into EDC, eCOA, CDMS and eConsent so a buyer can take only the pieces needed, and adds a Catalyst feature that extracts source data with AI while a person reviews each result. The EDC page offers three routes to a live study (self-service, assisted, or built by Castor), with deployment quoted at 3 to 12 weeks, plus data management and eCOA translation services.
The privacy policy names Ciwit B.V., known as Castor, at Fred. Roeskestraat 115 in Amsterdam, acting as processor for patient data in CDMS and eConsent and as controller for website and account data. The About page dates the start to 2012, as a project of Dr. Derk Arts. Buying runs through a form, a call, a protocol review and a demo, ending in an itemised proposal within 5 business days. The pages show no hosting region.
What Castor does well
- Modules can be taken separately
- Self-service, assisted or vendor-led build
- Open API for other systems
- Amsterdam entity named in the privacy policy
- Fixed-scope, itemised proposals
Where Castor falls short
- Data centre region absent from the pages checked
- Prices are not published
- 21 CFR Part 11 not mentioned on the EDC page
- Vendor services raise the total
Standout feature. Castor offers self-service, assisted and Castor-led builds of the same study under one platform.
Uppsala, Sweden
Pricing on request; single study licence or multiple licence model
Demo on request
Best for: CROs and sponsors running several studies in parallel under one licence model
Viedoc is a Swedish suite on one clinical database, covering EDC with drag-and-drop CRF design, ePRO, randomization, trial supply management, medical coding, televisits, record sharing, eSignature, reports, an API and an eTMF. The pricing page names a Single Study Model and a Multiple License Model, and the fee includes maintenance, hosting and technical support, with no setup fees when you build the study yourself.
The security page lists Uppsala as headquarters, with subsidiaries in Tokyo, Shanghai and Raleigh, and the home page says the system supports 7,500 clinical trials. It states ISO 27001:2022 across all Annex A controls and a SOC 2 Type 2 report on request. The privacy policy mentions transfers to the USA, and the hosting country and the legal form of the contracting company were not on the pages checked.
What Viedoc does well
- ISO 27001:2022 named on the security page
- SOC 2 Type 2 report available on request
- Wide module list, eTMF included
- Licence model for multiple concurrent studies
- Hosting and support covered by the licence
Where Viedoc falls short
- Hosting country not given
- Legal form missing from the pages checked
- Privacy policy allows transfers to the USA
- No amounts shown
Standout feature. Viedoc offers a multiple licence model for concurrent studies, with hosting and support inside the fee.
Berlin, Germany
Not published; the vendor cites an attractive price model
Demo on request
Best for: Academic trial units and registries with imaging data and changing form needs
secuTrial is a browser-based EDC that the vendor describes as GCP-compliant for clinical and non-interventional studies and patient registries. It lists seven randomization algorithms, double data entry for studies that begin on paper, pseudonymised image management with DICOM support, CDISC interfaces and patient apps for outcomes.
interActive Systems GmbH, whose imprint gives Glogauer Str. 19 in Berlin and register entry HRB 106103B at Berlin Charlottenburg, builds it. A news item says secuTrial and customer data are hosted at the noris network NBG6 facility in Nuremberg. According to the vendor, customer requests become functions through a validated process, and urgent ones can ship within weeks outside the release plan. Ownership and pricing are not stated.
What secuTrial does well
- Berlin imprint with a register number
- Hosting site named as Nuremberg
- Choice of seven randomization methods
- Handles DICOM images
- Double entry supported for paper capture
Where secuTrial falls short
- Prices not listed
- Data capture only, no CTMS or eTMF
- One hosting arrangement described
- Owner not named
Standout feature. secuTrial manages pseudonymised DICOM images inside the EDC, which suits imaging endpoints.
Paris, France
Founded 1999
Not published
Demo on request
Best for: Organisations wanting CTMS, eTMF and EDC from one vendor, or an on-premises installation
Ennov Clinical is the clinical range inside the Paris software house Ennov, covering CTMS, eTMF, EDC and RTSM. The CTMS handles oversight, monitoring and finances and calculates investigator payments from EDC data. The eTMF arrives with the TMF Reference Model structure, metadata-driven search and live QC status, and Ennov EDC offers no-code study design with built-in edit checks.
The privacy policy names Ennov SAS at 149 Avenue de France in Paris, the legal terms place the website under French law, and the About page dates the company to 1999. The vendor says more than 650 life sciences companies use Ennov. Cloud or on-premises deployment is possible, but regions are not stated, ownership is not described, and MACRO EDC and DataLabs EDC sit beside Ennov EDC without an explanation of how they relate.
What Ennov Clinical does well
- Four clinical products from one supplier
- Can be installed on the sponsor's own servers
- French entity named in the privacy policy
- eTMF preloaded with the reference model
- EDC studies designed without code
Where Ennov Clinical falls short
- Prices not published
- Cloud regions not given
- Three EDC products with unclear roles
- Catalogue extends well past clinical work
Standout feature. Ennov Clinical is the only tool here that combines CTMS, eTMF and EDC with an on-premises deployment option.
Giessen, Germany
Not published
Demo on request
Best for: Sponsors that want an eCRF built to order and a CRO in the same company
Alcedis Platforms is the software side of a digital clinical research organisation in Giessen, and its eCRF is custom-built to the protocol, with ready plugins for common processes. Mobile apps collect participant data such as quality of life and show project managers study progress, and a REST API connects Alcedis with third-party systems.
Alcedis GmbH is entered as HRB 3169 and listed at Winchesterstr. 3. The company says it launched Germany's first eCRF in 1998, and the eCRF page states that databases and interfaces run in its in-house cloud computing centre in Germany. The timeline records acquisition by Huma Therapeutics in 2023, whose own site gives a London headquarters. No certificates or prices are named on the pages checked.
What Alcedis Platforms does well
- Register entry in Giessen
- Cloud centre owned by the company, in Germany
- REST API for outside systems
- Participant apps on mobile
- Research experience since 1998
Where Alcedis Platforms falls short
- Built to order, not self-service
- No amounts shown
- No certificates named
- Software and CRO services come together
Standout feature. Alcedis builds each eCRF to the protocol and runs it in its own computing centre in Germany.
Baden, Switzerland
Founded 1996
Not published
Demo on request
Best for: Sponsors whose gap is trial operations and the master file, not data capture
BSI Life Sciences sells a CTMS that bundles trial management, a master file, start-up, training and supply modules, and an eTMF that runs standalone or inside the CTMS. The TMF can follow the reference document structure or any other one by configuration, reporting and access rights are set the same way, and a standard API links existing systems.
The unit belongs to BSI Business Systems Integration AG, a private Swiss software company with offices in Baden (Täfernweg 1), Munich and New Jersey. The page says the firm has built software for over 25 years across Switzerland, Germany and the United States, with the life sciences range going back to 1996. Switzerland is outside the EU but counts as European here. No EDC, certification, hosting option or price appears on the pages checked.
What BSI Life Sciences does well
- CTMS and eTMF sold apart or together
- Start-up, training and supply modules
- Standard API
- Swiss company named on the site
- TMF structure can be configured
Where BSI Life Sciences falls short
- Does not offer EDC
- Certifications not named
- Hosting not described
- Prices not published
Standout feature. BSI Life Sciences sells its eTMF either on its own or inside the CTMS, so a team can start with the master file.
Zurich, Switzerland
Not published
Demo on request
Best for: Registries and patient-reported outcome studies, for instance in dermatology
CRF.one is a questionnaire and registry tool with a dynamic builder for conditional logic and longitudinal assessments. The page names PRO instruments including PHQ-9, GAD-7 and DLQI, adds automated reminders, electronic informed consent, dashboards, CSV, Excel and PDF export, and role-based access, with a white-label option. It supports multi-centre and multi-country studies.
The Impressum lists Swiss4ward GmbH at Böcklinstrasse 35 in Zurich, which runs other platforms such as DermaCompass and Cyberderm next to consulting. The site says CRF.one is hosted exclusively in Switzerland and the EEA, meets GDPR Article 9 requirements for health data and comes with a Data Processing Agreement as standard. It makes no GCP or 21 CFR Part 11 claim, and has no randomization, CTMS or eTMF.
What CRF.one does well
- Hosting restricted to Switzerland and the EEA
- Data Processing Agreement supplied
- PRO instruments listed by name
- Consent handled electronically
- Zurich company in the Impressum
Where CRF.one falls short
- No validation claim for interventional studies
- No randomization, CTMS or eTMF
- No amounts shown
- Small vendor with consulting alongside
Standout feature. CRF.one ships with a Data Processing Agreement as standard and hosts only in Switzerland and the EEA.
